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代谢疾病Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

期刊：Proceedings of the National Academy of Sciences of the United States of America发表年份：2012作者：Kaleeckal G Harikumar; Denise Wootten; Delia I Pinon; Cassandra Koole; Alicja M Ball; Sebastian G B Furness; Bim Graham; Maoqing Dong; Arthur Christopoulos; Laurence J Miller; Patrick M Sexton
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代谢疾病3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.

期刊：Journal of medicinal chemistry发表年份：2012作者：Istvan Macsari; Yevgeni Besidski; Gabor Csjernyik; Linda I Nilsson; Lars Sandberg; Ulrika Yngve; Kristofer Ahlin; Tjerk Bueters; Anders B Eriksson; Per-Eric Lund; Elisabet Venyike; Sandra Oerther; Karin Hygge Blakeman; Lei Luo; Per I Arvidsson
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代谢疾病Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

期刊：ChemMedChem发表年份：2012作者：Claudia Mugnaini; Stefania Nocerino; Valentina Pedani; Serena Pasquini; Andrea Tafi; Maria De Chiaro; Luca Bellucci; Massimo Valoti; Francesca Guida; Livio Luongo; Stefania Dragoni; Alessia Ligresti; Avraham Rosenberg; Daniele Bolognini; Maria Grazia
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代谢疾病The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes.

期刊：Molecular nutrition & food research发表年份：2012作者：Yaoyao Jia; Jin-Young Kim; Hee-Jin Jun; Sun-Joong Kim; Ji-Hae Lee; Minh Hien Hoang; Kwang-Yeon Hwang; Soo-Jong Um; Hyo Ihl Chang; Sung-Joon Lee
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