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代谢疾病Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice.

期刊:British journal of pharmacology发表年份:2010作者:Masahiko Ito; A Ishihara; A Gomori; H Matsushita; Makoto Ito; J M Metzger; D J Marsh; Y Haga; H Iwaasa; S Tokita; N Takenaga; N Sato; D J MacNeil; M Moriya; A Kanatani

代谢疾病Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes.

期刊:Molecular therapy : the journal of the American Society of Gene Therapy发表年份:2010作者:Damien Bresson; Matthew Fradkin; Yulia Manenkova; Diane Rottembourg; Matthias von Herrath

代谢疾病Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

期刊:Molecular pharmacology发表年份:2010作者:Cassandra Koole; Denise Wootten; John Simms; Celine Valant; Rohan Sridhar; Owen L Woodman; Laurence J Miller; Roger J Summers; Arthur Christopoulos; Patrick M Sexton

代谢疾病(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.

期刊:Journal of medicinal chemistry发表年份:2010作者:Hiroyuki Kakinuma; Takahiro Oi; Yuko Hashimoto-Tsuchiya; Masayuki Arai; Yasunori Kawakita; Yoshiki Fukasawa; Izumi Iida; Naoko Hagima; Hiroyuki Takeuchi; Yukihiro Chino; Jun Asami; Lisa Okumura-Kitajima; Fusayo Io; Daisuke Yamamoto; Noriyuki Miyata;