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基因编辑仓鼠AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model.

期刊：Neuropharmacology发表年份：2010作者：Stefania Risso Bradley; Jelveh Lameh; Linda Ohrmund; Thomas Son; Abhishek Bajpai; Derek Nguyen; Mikael Friberg; Ethan S Burstein; Tracy A Spalding; Thomas R Ott; Hans H Schiffer; Ali Tabatabaei; Krista McFarland; Robert E Davis; Douglas W Bonhaus
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基因编辑仓鼠SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells.

期刊：Journal of immunology (Baltimore, Md. : 1950)发表年份：2010作者：Carla C Fowler; Lily I Pao; Joseph N Blattman; Philip D Greenberg
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基因编辑仓鼠Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

期刊：Neuron发表年份：2010作者：Maria Z Kounnas; Anne M Danks; Soan Cheng; Curtis Tyree; Elizabeth Ackerman; Xulun Zhang; Kwangwook Ahn; Phuong Nguyen; Dan Comer; Long Mao; Chengzhi Yu; David Pleynet; Paul J Digregorio; Gonul Velicelebi; Kenneth A Stauderman; William T Comer; Willi
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基因编辑仓鼠The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta.

期刊：Journal of cellular biochemistry发表年份：2010作者：Min-Su Han; Hyo-Jin Kim; Hee-Jun Wee; Kyung-Eun Lim; Na-Rae Park; Suk-Chul Bae; Andre J van Wijnen; Janet L Stein; Jane B Lian; Gary S Stein; Je-Yong Choi
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