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代谢疾病Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.

期刊：Journal of medicinal chemistry发表年份：2012作者：Satoshi Mikami; Shuji Kitamura; Nobuyuki Negoro; Shinobu Sasaki; Masami Suzuki; Yoshiyuki Tsujihata; Takeshi Miyazaki; Ryo Ito; Nobuhiro Suzuki; Junichi Miyazaki; Takashi Santou; Naoyuki Kanzaki; Miyuki Funami; Toshimasa Tanaka; Tsuneo Yasuma; Yu Mom
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代谢疾病DA-1229, a novel and potent DPP4 inhibitor, improves insulin resistance and delays the onset of diabetes.

期刊：Life sciences发表年份：2012作者：Mi-Kyung Kim; Yu Na Chae; Ha Dong Kim; Eun Kyoung Yang; Eun Jung Cho; Song-hyen Choi; Ye-Hwang Cheong; Hae-Sun Kim; Heung Jae Kim; Yeong Woo Jo; Moon-Ho Son; Soon-Hoe Kim; Chang Yell Shin
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代谢疾病Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines.

期刊：Diabetologia发表年份：2012作者：Z X Meng; Y Yin; J H Lv; M Sha; Y Lin; L Gao; Y X Zhu; Y J Sun; X Han
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代谢疾病Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.

期刊：Biopolymers发表年份：2012作者：Jonathan W Day; Vasily Gelfanov; David Smiley; Paul E Carrington; George Eiermann; Gary Chicchi; Mark D Erion; Jas Gidda; Nancy A Thornberry; Matthias H Tschöp; Donald J Marsh; Ranabir SinhaRoy; Richard DiMarchi; Alessandro Pocai
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