代谢疾病Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
期刊：Journal of medicinal chemistry发表年份：2010作者：Lin Yan; Pei Huo; John S Debenham; Christina B Madsen-Duggan; Julie Lao; Richard Z Chen; Jing Chen Xiao; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Nancy Tsou; Richard G Ball; Junying Wang; Xinchun Tong; Thomas J Bateman; V