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药效评价Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.

期刊:European journal of medicinal chemistry发表年份:2023作者:Manuela Jörg; Emma T van der Westhuizen; Yao Lu; K H Christopher Choy; David M Shackleford; Elham Khajehali; Andrew B Tobin; David M Thal; Ben Capuano; Arthur Christopoulos; Celine Valant; Peter J Scammells

药效评价Universal protocol and standard-spiking strategy for profiling of host cell proteins in therapeutic growth hormone.

期刊:Analytical biochemistry发表年份:2023作者:Feng Liu; Weicheng Ren; Hailong Liu; Hao Liu; Shuyue Wang; Di Zhang; Dandan Sun; Feifei Zhang; Zhengkang Shao; Jia Feng; Menghan Yan; Lan Yang; Zhiwei Wang; Jinliang Zhang; Yingwu Wang

药效评价A genetic off-target event in a site-specific integration cell line expressing monoclonal antibody has no impact on commercial suitability.

期刊:Biotechnology progress发表年份:2023作者:Barbara Tevelev; Andre Chambers; Swap Ghosh; Ying Zhang; Lisa Marzili; Jason C Rouse; Shu Han; Mark Moffat; John J Scarcelli

药效评价Identification and Quantification of a Problematic Host Cell Protein to Support Therapeutic Protein Development.

期刊:Journal of pharmaceutical sciences发表年份:2023作者:Sook Yen E; Yunli Hu; Rosalynn Molden; Haibo Qiu; Ning Li