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药效评价Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2021作者:Julie V Selkirk; Kevin C Dines; Yingzhuo Grace Yan; Nathan Ching; Deepak Dalvie; Shameek Biswas; Andrea Bortolato; Jeffrey M Schkeryantz; Carlos Lopez; Iliana Ruiz; Richard Hargreaves

药效评价Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis.

期刊:Neuropharmacology发表年份:2021作者:Faik Imeri; Bisera Stepanovska Tanturovska; Aleksandra Zivkovic; Gaby Enzmann; Stephanie Schwalm; Josef Pfeilschifter; Thomas Homann; Burkhard Kleuser; Britta Engelhardt; Holger Stark; Andrea Huwiler

药效评价Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo.

期刊:Journal of medicinal chemistry发表年份:2021作者:Fumihiro Kawagoe; Aileen Mendoza; Yuki Hayata; Lisa Asano; Kenjiro Kotake; Sayuri Mototani; Satoshi Kawamura; Shigeyuki Kurosaki; Yusuke Akagi; Yasushi Takemoto; Kazuo Nagasawa; Hayato Nakagawa; Motonari Uesugi; Atsushi Kittaka

药效评价In Vitro and In Vivo Pharmaco-Toxicological Characterization of 1-Cyclohexyl-x-methoxybenzene Derivatives in Mice: Comparison with Tramadol and PCP.

期刊:International journal of molecular sciences发表年份:2021作者:Sabrine Bilel; Micaela Tirri; Raffaella Arfè; Chiara Sturaro; Anna Fantinati; Virginia Cristofori; Tatiana Bernardi; Federica Boccuto; Marco Cavallo; Alessandro Cavalli; Fabio De-Giorgio; Girolamo Calò; Matteo Marti