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药效评价Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2018作者:Susanne Neumann; Elena Eliseeva; Alisa Boutin; Elena Barnaeva; Marc Ferrer; Noel Southall; David Kim; Xin Hu; Sarah J Morgan; Juan J Marugan; Marvin C Gershengorn

药效评价Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.

期刊:British journal of pharmacology发表年份:2018作者:Sarah A Nickolls; Rachel Gurrell; Guido van Amerongen; Juha Kammonen; Lishuang Cao; Adam R Brown; Clara Stead; Andy Mead; Christine Watson; Cathleen Hsu; Robert M Owen; Andy Pike; Rebecca L Fish; Laigao Chen; Ruolun Qiu; Evan D Morris; Gang Feng; Mar

药效评价Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.

期刊:Molecular pharmacology发表年份:2018作者:Sophie J Bradley; Colin Molloy; Christoffer Bundgaard; Adrian J Mogg; Karen J Thompson; Louis Dwomoh; Helen E Sanger; Michael D Crabtree; Simon M Brooke; Patrick M Sexton; Christian C Felder; Arthur Christopoulos; Lisa M Broad; Andrew B Tobin; Christ

药效评价Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates.

期刊:Molecular pharmacology发表年份:2018作者:Philip J Sandoval; Kimberley M Zorn; Alex M Clark; Sean Ekins; Stephen H Wright