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药效评价Structure⁻Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells.

期刊:International journal of molecular sciences发表年份:2018作者:Yuri Campelo; Alicia Ombredane; Andreanne G Vasconcelos; Lucas Albuquerque; Daniel C Moreira; Alexandra Plácido; Jefferson Rocha; Harold Hilarion Fokoue; Lydia Yamaguchi; Ana Mafud; Yvonne P Mascarenhas; Cristina Delerue-Matos; Tatiana Borges; Grazie

药效评价Impact of allosteric modulation: Exploring the binding kinetics of glutamate and other orthosteric ligands of the metabotropic glutamate receptor 2.

期刊:Biochemical pharmacology发表年份:2018作者:Maarten L J Doornbos; Sophie C Vermond; Hilde Lavreysen; Gary Tresadern; Adriaan P IJzerman; Laura H Heitman

药效评价Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time.

期刊:Biochemical pharmacology发表年份:2018作者:Marjolein Soethoudt; Mark W H Hoorens; Ward Doelman; Andrea Martella; Mario van der Stelt; Laura H Heitman

药效评价Biased antagonism of CXCR4 avoids antagonist tolerance.

期刊:Science signaling发表年份:2018作者:Ben Hitchinson; Jonathan M Eby; Xianlong Gao; Francois Guite-Vinet; Joshua J Ziarek; Hazem Abdelkarim; Youngshim Lee; Yukari Okamoto; Sojin Shikano; Matthias Majetschak; Nikolaus Heveker; Brian F Volkman; Nadya I Tarasova; Vadim Gaponenko