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药效评价7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.

期刊：Bioorganic & medicinal chemistry发表年份：2018作者：Hui-Jiao Sun; Yu-Hua Wang; Cong-Min Yuan; Ling-Hui Kong; Xue-Jun Xu; Yu-Jun Wang; Hai-Hao Wu; Cheng Lin; Yuan-Yuan Qian; Huo-Ming Huang; Li Xiao; Xiao Liu; Qian He; Sheng-Yang Fang; Deng-Qi Xue; Xi-Cheng Yang; Hao Chen; Yi-Lin Zheng; Lan Zheng; Lin-Q
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药效评价Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

期刊：Proceedings of the National Academy of Sciences of the United States of America发表年份：2018作者：Kay L Richards; Carol J Milligan; Robert J Richardson; Nikola Jancovski; Morten Grunnet; Laura H Jacobson; Eivind A B Undheim; Mehdi Mobli; Chun Yuen Chow; Volker Herzig; Agota Csoti; Gyorgy Panyi; Christopher A Reid; Glenn F King; Steven Petrou
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药效评价Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study.

期刊：Molecules (Basel, Switzerland)发表年份：2018作者：Ruyin Cao; Alejandro Giorgetti; Andreas Bauer; Bernd Neumaier; Giulia Rossetti; Paolo Carloni
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药效评价Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis.

期刊：Journal of immunology research发表年份：2018作者：Ronan O'Dwyer; Marina Kovaleva; Jiquan Zhang; John Steven; Emma Cummins; Deborah Luxenberg; Alfredo Darmanin-Sheehan; Miguel F Carvalho; Matthew Whitters; Kenneth Saunders; Caroline J Barelle
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