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药效评价Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).

期刊:Journal of medicinal chemistry发表年份:2018作者:Pauline W Ondachi; Chad M Kormos; Scott P Runyon; James B Thomas; S Wayne Mascarella; Ann M Decker; Hernán A Navarro; Timothy R Fennell; Rodney W Snyder; F Ivy Carroll

药效评价The Properties of Cysteine-Conjugated Antibody-Drug Conjugates Are Impacted by the IgG Subclass.

期刊:The AAPS journal发表年份:2018作者:Amita Datta-Mannan; Hiuwan Choi; David Stokell; Jason Tang; Anthony Murphy; Aaron Wrobleski; Yiqing Feng

药效评价Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease-like neuropathology.

期刊:Glia发表年份:2018作者:Siok Lam Lim; Diana Nguyen Tran; Joannee Zumkehr; Christine Chen; Sagar Ghiaar; Zanett Kieu; Emmanuel Villanueva; Victoria Gallup; Carlos J Rodriguez-Ortiz; Masashi Kitazawa

药效评价Rapid and low-cost multiplex synthesis of chemokine analogs.

期刊:The Journal of biological chemistry发表年份:2018作者:Marianne Paolini-Bertrand; Fabrice Cerini; Elsa Martins; Ilaria Scurci; Oliver Hartley