药效评价Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
期刊：Journal of medicinal chemistry发表年份：2016作者：Jose María Cid; Gary Tresadern; Juan Antonio Vega; Ana Isabel de Lucas; Alcira Del Cerro; Encarnación Matesanz; María Lourdes Linares; Aránzazu García; Laura Iturrino; Laura Pérez-Benito; Gregor J Macdonald; Daniel Oehlrich; Hilde Lavreysen; Luc Peet