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基因编辑仓鼠Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

期刊:Journal of virology发表年份:2015作者:Bastian Thaa; Roberta Biasiotto; Kai Eng; Maarit Neuvonen; Benjamin Götte; Lara Rheinemann; Margit Mutso; Age Utt; Finny Varghese; Giuseppe Balistreri; Andres Merits; Tero Ahola; Gerald M McInerney

基因编辑仓鼠A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2015作者:Pascal Bonaventure; Sujin Yun; Philip L Johnson; Anantha Shekhar; Stephanie D Fitz; Brock T Shireman; Terry P Lebold; Diane Nepomuceno; Brian Lord; Michelle Wennerholm; Jonathan Shelton; Nicholas Carruthers; Timothy Lovenberg; Christine Dugovic

基因编辑仓鼠A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

期刊:Molecular neurodegeneration发表年份:2015作者:Ulf Neumann; Heinrich Rueeger; Rainer Machauer; Siem Jacob Veenstra; Rainer M Lueoend; Marina Tintelnot-Blomley; Grit Laue; Karen Beltz; Barbara Vogg; Peter Schmid; Wilfried Frieauff; Derya R Shimshek; Matthias Staufenbiel; Laura H Jacobson

基因编辑仓鼠Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.

期刊:Molecular neurodegeneration发表年份:2015作者:Joo In Jung; Ashleigh R Price; Thomas B Ladd; Yong Ran; Hyo-Jin Park; Carolina Ceballos-Diaz; Lisa A Smithson; Günther Hochhaus; Yufei Tang; Rajender Akula; Saritha Ba; Edward H Koo; Gideon Shapiro; Kevin M Felsenstein; Todd E Golde