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肿瘤模型FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.

期刊:Molecular oncology发表年份:2020作者:Marta Pozniak; Aleksandra Sokolowska-Wedzina; Kamil Jastrzebski; Jakub Szymczyk; Natalia Porebska; Mateusz Adam Krzyscik; Malgorzata Zakrzewska; Marta Miaczynska; Jacek Otlewski; Lukasz Opalinski

肿瘤模型Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents.

期刊:European journal of medicinal chemistry发表年份:2020作者:Costanza Ceni; Daniela Catarzi; Flavia Varano; Diego Dal Ben; Gabriella Marucci; Michela Buccioni; Rosaria Volpini; Andrea Angeli; Alessio Nocentini; Paola Gratteri; Claudiu T Supuran; Vittoria Colotta

肿瘤模型Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer.

期刊:Molecules (Basel, Switzerland)发表年份:2020作者:Sahar B Kandil; Samuel R Jones; Sonia Smith; Stephen E Hiscox; Andrew D Westwell

肿瘤模型Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity.

期刊:Cancer immunology research发表年份:2020作者:Helen Kotanides; Yiwen Li; Maria Malabunga; Carmine Carpenito; Scott W Eastman; Yang Shen; George Wang; Ivan Inigo; David Surguladze; Anthony L Pennello; Krishnadatt Persaud; Sagit Hindi; Michael Topper; Xinlei Chen; Yiwei Zhang; Danielle K Bulaon; T