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药效评价Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor.

期刊:Archives of pharmacal research发表年份:2015作者:Hyeon Young Kim; Vithal B Jadhav; Dae Young Jeong; Woo Kyu Park; Jong-Hwan Song; Sunkyung Lee; Heeyeong Cho

药效评价Pyridoxamine and pyridoxal are more effective than pyridoxine in rescuing folding-defective variants of human alanine:glyoxylate aminotransferase causing primary hyperoxaluria type I.

期刊:Human molecular genetics发表年份:2015作者:Elisa Oppici; Sonia Fargue; Emma S Reid; Philippa B Mills; Peter T Clayton; Christopher J Danpure; Barbara Cellini

药效评价Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

期刊:Journal of medicinal chemistry发表年份:2015作者:Takashi Nagahara; Tsuyoshi Saitoh; Noriki Kutsumura; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Daisuke Kuroda; Hiroaki Gouda; Hidetoshi Kumagai; Hideaki Fujii; Masashi Yanagisawa; Hiroshi Nagase

药效评价The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

期刊:Proteomics发表年份:2015作者:Stan Pasyk; Steven Molinski; Saumel Ahmadi; Mohabir Ramjeesingh; Ling-Jun Huan; Stephanie Chin; Kai Du; Herman Yeger; Paul Taylor; Michael F Moran; Christine E Bear