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药效评价Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations.

期刊:Journal of chemical information and modeling发表年份:2015作者:Zhiwei Feng; Larry V Pearce; Xiaomeng Xu; Xiaole Yang; Peng Yang; Peter M Blumberg; Xiang-Qun Xie

药效评价Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor.

期刊:ACS chemical neuroscience发表年份:2015作者:David A Perrey; Nadezhda A German; Ann M Decker; David Thorn; Jun-Xu Li; Brian P Gilmour; Brian F Thomas; Danni L Harris; Scott P Runyon; Yanan Zhang

药效评价A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1.

期刊:Journal of biomolecular screening发表年份:2015作者:Paul D Wright; Srinivasan Kanumilli; David Tickle; Jamie Cartland; Nathalie Bouloc; Timothy Dale; Derek J Tresize; Conor McCloskey; Samantha McCavera; Andrew M Blanks; Catherine Kettleborough; Jeffrey C Jerman

药效评价Identification of G protein-biased agonists that fail to recruit β-arrestin or promote internalization of the D1 dopamine receptor.

期刊:ACS chemical neuroscience发表年份:2015作者:Jennie L Conroy; R Benjamin Free; David R Sibley