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药效评价Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans.

期刊:Alzheimer's research & therapy发表年份:2015作者:I-Fang Ling; Todd E Golde; Douglas R Galasko; Edward H Koo

药效评价Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

期刊:Toxicology mechanisms and methods发表年份:2015作者:Dolores Diaz; Donna Dambach; Michael Siu; Kevin Hunt; Allen Thomas; Joseph Lyssikatos; Xingrong Liu; Sock Lewin-Koh; Bobby McCray; Kevin Ford

药效评价Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.

期刊:Journal of medicinal chemistry发表年份:2015作者:Justin K Murray; Yi-Xin Qian; Benxian Liu; Robin Elliott; Jennifer Aral; Cynthia Park; Xuxia Zhang; Michael Stenkilsson; Kevin Salyers; Mark Rose; Hongyan Li; Steven Yu; Kristin L Andrews; Anne Colombero; Jonathan Werner; Kevin Gaida; E Allen Sickmie

药效评价The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

期刊:PLoS neglected tropical diseases发表年份:2015作者:Anna Crisford; Ulrich Ebbinghaus-Kintscher; Eva Schoenhense; Achim Harder; Klaus Raming; Ita O'Kelly; Kelechi Ndukwe; Vincent O'Connor; Robert J Walker; Lindy Holden-Dye