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药效评价Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.

期刊:mAbs发表年份:2014作者:John A Corbin; Vinay Bhaskar; Ira D Goldfine; Hassan Issafras; Daniel H Bedinger; Angela Lau; Kristen Michelson; Lisa M Gross; Betty A Maddux; Hua F Kuan; Catarina Tran; Llewelyn Lao; Masahisa Handa; Susan R Watson; Ajay J Narasimha; Shirley Zhu; Rap

药效评价Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.

期刊:Journal of medicinal chemistry发表年份:2014作者:Akshata Nayak; Girish Chandra; Inah Hwang; Kyunglim Kim; Xiyan Hou; Hea Ok Kim; Pramod K Sahu; Kuldeep K Roy; Jakyung Yoo; Yoonji Lee; Minghua Cui; Sun Choi; Steven M Moss; Khai Phan; Zhan-Guo Gao; Hunjoo Ha; Kenneth A Jacobson; Lak Shin Jeong

药效评价VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.

期刊:Chemistry & biology发表年份:2014作者:Paul D W Eckford; Mohabir Ramjeesingh; Steven Molinski; Stan Pasyk; Johanna F Dekkers; Canhui Li; Saumel Ahmadi; Wan Ip; Timothy E Chung; Kai Du; Herman Yeger; Jeffrey Beekman; Tanja Gonska; Christine E Bear

药效评价Linear short histidine and cysteine modified arginine peptides constitute a potential class of DNA delivery agents.

期刊:Molecular pharmaceutics发表年份:2014作者:Anita Mann; Vasundhara Shukla; Richa Khanduri; Spoorti Dabral; Harpal Singh; Munia Ganguli