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药效评价A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.

期刊:The Journal of neuroscience : the official journal of the Society for Neuroscience发表年份:2013作者:Annika Thorsell; Jenica D Tapocik; Ke Liu; Michelle Zook; Lauren Bell; Meghan Flanigan; Samarjit Patnaik; Juan Marugan; Ruslan Damadzic; Seameen J Dehdashti; Melanie L Schwandt; Noel Southall; Christopher P Austin; Robert Eskay; Roberto Ciccocioppo;

药效评价Understanding the cellular function of TRPV2 channel through generation of specific monoclonal antibodies.

期刊:PloS one发表年份:2013作者:Matthew R Cohen; Kevin W Huynh; Daniel Cawley; Vera Y Moiseenkova-Bell

药效评价Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

期刊:Bioorganic & medicinal chemistry letters发表年份:2013作者:Douglas J Sheffler; Christian Sevel; Uyen Le; Kimberly M Lovell; James C Tarr; Sheridan J S Carrington; Hyekyung P Cho; Gregory J Digby; Colleen M Niswender; P Jeffrey Conn; Corey R Hopkins; Michael R Wood; Craig W Lindsley

药效评价5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair.

期刊:Nucleic acids research发表年份:2013作者:Manuel Luís Orta; José Manuel Calderón-Montaño; Inmaculada Domínguez; Nuria Pastor; Estefanía Burgos-Morón; Miguel López-Lázaro; Felipe Cortés; Santiago Mateos; Thomas Helleday