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药效评价Towards a modern definition of vitamin E-evidence for a quinone hypothesis.

期刊:Bioorganic & medicinal chemistry letters发表年份:2012作者:William D Shrader; Akiko Amagata; Adam Barnes; Andrew Hinman; Orion Jankowski; Edgar Lee; Viktoria Kheifets; Ryo Komatsuzaki; Paul Mollard; Katsuyuki Murase; Patrice Rioux; Kieron Wesson; Guy Miller

药效评价Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity.

期刊:Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association发表年份:2012作者:Anastasia Messer; Nicole Raquet; Christiane Lohr; Dieter Schrenk

药效评价Native-state solubility and transfer free energy as predictive tools for selecting excipients to include in protein formulation development studies.

期刊:Journal of pharmaceutical sciences发表年份:2012作者:Douglas D Banks; Ramil F Latypov; Randal R Ketchem; Jon Woodard; Joanna L Scavezze; Christine C Siska; Vladimir I Razinkov

药效评价The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.

期刊:Journal of medicinal chemistry发表年份:2012作者:Martin H Bolli; Christoph Boss; Christoph Binkert; Stephan Buchmann; Daniel Bur; Patrick Hess; Marc Iglarz; Solange Meyer; Josiane Rein; Markus Rey; Alexander Treiber; Martine Clozel; Walter Fischli; Thomas Weller