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药效评价Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.

期刊:Journal of medicinal chemistry发表年份:2012作者:Anatoly A Mazurov; Lan Miao; Balwinder S Bhatti; Jon-Paul Strachan; Srinivasa Akireddy; Srinivasa Murthy; David Kombo; Yun-de Xiao; Philip Hammond; Jenny Zhang; Terry A Hauser; Kristen G Jordan; Craig H Miller; Jason D Speake; Gregory J Gatto; Daniel

药效评价Total synthesis and biological evaluation of phidianidines A and B uncovers unique pharmacological profiles at CNS targets.

期刊:ACS chemical neuroscience发表年份:2012作者:John T Brogan; Sydney L Stoops; Craig W Lindsley

药效评价Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells.

期刊:The Journal of biological chemistry发表年份:2012作者:Linda Wildling; Christian Rankl; Thomas Haselgrübler; Hermann J Gruber; Marion Holy; Amy Hauck Newman; Mu-Fa Zou; Rong Zhu; Michael Freissmuth; Harald H Sitte; Peter Hinterdorfer

药效评价Effects of halogenation on tyrosine phosphorylation and peptide binding to the SRC homology 2 domain of lymphocyte-specific protein tyrosine kinase.

期刊:Biological & pharmaceutical bulletin发表年份:2012作者:Toshimitsu Okamura; Tatsuya Kikuchi; Mika Nodaira; Kenichi Odaka; Kiyoshi Fukushi; Toshiaki Irie