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药效评价Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.

期刊:The Journal of neuroscience : the official journal of the Society for Neuroscience发表年份:2012作者:Gregory J Digby; Meredith J Noetzel; Michael Bubser; Thomas J Utley; Adam G Walker; Nellie E Byun; Evan P Lebois; Zixiu Xiang; Douglas J Sheffler; Hyekyung P Cho; Albert A Davis; Natali E Nemirovsky; Sarah E Mennenga; Bryan W Camp; Heather A Bimonte-

药效评价Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.

期刊:Journal of medicinal chemistry发表年份:2012作者:Adolfo Prandi; Silvia Franchini; Leda Ivanova Manasieva; Paola Fossa; Elena Cichero; Gabriella Marucci; Michela Buccioni; Antonio Cilia; Lorenza Pirona; Livio Brasili

药效评价Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer.

期刊:The Journal of biological chemistry发表年份:2012作者:Sanam Mustafa; Heng B See; Ruth M Seeber; Stephen P Armstrong; Carl W White; Sabatino Ventura; Mohammed Akli Ayoub; Kevin D G Pfleger

药效评价Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.

期刊:The Journal of neuroscience : the official journal of the Society for Neuroscience发表年份:2012作者:M Camila Almeida; Tamara Hew-Butler; Renato N Soriano; Sara Rao; Weiya Wang; Judy Wang; Nuria Tamayo; Daniela L Oliveira; Tatiane B Nucci; Prafulla Aryal; Andras Garami; Diana Bautista; Narender R Gavva; Andrej A Romanovsky