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药效评价Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recepto

期刊:Journal of medicinal chemistry发表年份:2011作者:Carrie K Jones; Darren W Engers; Analisa D Thompson; Julie R Field; Anna L Blobaum; Stacey R Lindsley; Ya Zhou; Rocco D Gogliotti; Satyawan Jadhav; Rocio Zamorano; Jim Bogenpohl; Yoland Smith; Ryan Morrison; J Scott Daniels; C David Weaver; P Jeffrey

药效评价Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active.

期刊:Anesthesiology发表年份:2011作者:Sarah M Brown; Michael Holtzman; Thomas Kim; Evan D Kharasch

药效评价Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.

期刊:Molecular pharmacology发表年份:2011作者:Gautam Bhave; Brian A Chauder; Wen Liu; Eric S Dawson; Rishin Kadakia; Thuy T Nguyen; L Michelle Lewis; Jens Meiler; C David Weaver; Lisa M Satlin; Craig W Lindsley; Jerod S Denton

药效评价Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2011作者:Tae Ho Lee; Ki Hyun Kim; Sung Ok Lee; Kang Ro Lee; Miwon Son; Mirim Jin