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药效评价Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function.

期刊：Journal of medicinal chemistry发表年份：2011作者：Edgardo Laborde; Robert W Macsata; Fanying Meng; Brian T Peterson; Louise Robinson; Steve R Schow; Reyna J Simon; Hua Xu; Kunihisa Baba; Hideaki Inagaki; Yoshiro Ishiwata; Takahito Jomori; Yukiharu Matsumoto; Atsushi Miyachi; Takashi Nakamura; Masayu

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药效评价New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.

期刊：Journal of medicinal chemistry发表年份：2011作者：Pier Giovanni Baraldi; Delia Preti; Abdel Naser Zaid; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Stefania Baraldi; Romeo Romagnoli; Allan R Moorman; Katia Varani; Sandro Cosconati; Salvatore Di Maro; Luciana Marinelli; Ettore Novellino; Pier Andrea B

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药效评价TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.

期刊：The Journal of pharmacology and experimental therapeutics发表年份：2011作者：Yoshiyuki Tsujihata; Ryo Ito; Masami Suzuki; Ayako Harada; Nobuyuki Negoro; Tsuneo Yasuma; Yu Momose; Koji Takeuchi

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药效评价In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE).

期刊：Neuropharmacology发表年份：2011作者：Elisabetta Perdona'; Vivian J A Costantini; Michela Tessari; Prisca Martinelli; Corrado Carignani; Enzo Valerio; M H Selina Mok; Laura Zonzini; Filippo Visentini; Massimo Gianotti; Laurie Gordon; Magalie Rocheville; Mauro Corsi; Anna Maria Capelli

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