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药效评价The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D₂ and serotonin 5-HT₁A receptors.

期刊:European journal of pharmacology发表年份:2011作者:Peter Heusler; Liesbeth Bruins Slot; Amélie Tourette; Stéphanie Tardif; Didier Cussac

药效评价Dynamic mass redistribution as a means to measure and differentiate signaling via opioid and cannabinoid receptors.

期刊:Assay and drug development technologies发表年份:2011作者:Ellen E Codd; John R Mabus; Brian S Murray; Sui-Po Zhang; Christopher M Flores

药效评价Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

期刊:The Journal of neuroscience : the official journal of the Society for Neuroscience发表年份:2011作者:Bo Duan; Yi-Zhi Wang; Tao Yang; Xiang-Ping Chu; Ye Yu; Yu Huang; Hui Cao; Jillian Hansen; Roger P Simon; Michael X Zhu; Zhi-Gang Xiong; Tian-Le Xu

药效评价The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2011作者:Taline V Khroyan; Willma E Polgar; Gerta Cami-Kobeci; Stephen M Husbands; Nurulain T Zaveri; Lawrence Toll