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药效评价Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

期刊:Journal of medicinal chemistry发表年份:2010作者:Anette G Sams; Morten Hentzer; Gitte K Mikkelsen; Krestian Larsen; Christoffer Bundgaard; Niels Plath; Claus T Christoffersen; Benny Bang-Andersen

药效评价The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes.

期刊:The Journal of biological chemistry发表年份:2010作者:Yong Zhou; Sarah J Plowman; Lenard M Lichtenberger; John F Hancock

药效评价A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.

期刊:Assay and drug development technologies发表年份:2010作者:William A Schmalhofer; Andrew M Swensen; Brande S Thomas; John P Felix; Rodolfo J Haedo; Kelli Solly; Laszlo Kiss; Gregory J Kaczorowski; Maria L Garcia

药效评价Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.

期刊:Assay and drug development technologies发表年份:2010作者:Beiyan Zou; Haibo Yu; Joseph J Babcock; Pritam Chanda; Joel S Bader; Owen B McManus; Min Li