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基因编辑仓鼠N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.

期刊：Journal of pharmaceutical sciences发表年份：2009作者：Amit S Kalgutkar; Kosea S Frederick; Jonathan Chupka; Bo Feng; Sarah Kempshall; Rochelle J Mireles; Katherine S Fenner; Matthew D Troutman

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基因编辑仓鼠A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.

期刊：The Journal of neuroscience : the official journal of the Society for Neuroscience发表年份：2009作者：Jana K Shirey; Ashley E Brady; Paulianda J Jones; Albert A Davis; Thomas M Bridges; J Phillip Kennedy; Satyawan B Jadhav; Usha N Menon; Zixiu Xiang; Mona L Watson; Edward P Christian; James J Doherty; Michael C Quirk; Dean H Snyder; James J Lah; Alla

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基因编辑仓鼠Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

期刊：The Journal of biological chemistry发表年份：2009作者：Tatsuya Hoshino; Takushi Namba; Masaya Takehara; Tadashi Nakaya; Yukihiko Sugimoto; Wataru Araki; Shuh Narumiya; Toshiharu Suzuki; Tohru Mizushima

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基因编辑仓鼠Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.

期刊：Cellular signalling发表年份：2009作者：Sheng-Jian Li; Ten-Yang Yen; Yoshimi Endo; Malgorzata Klauzinska; Bolormaa Baljinnyam; Bruce Macher; Robert Callahan; Jeffrey S Rubin

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