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药效评价AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.

期刊:British journal of pharmacology发表年份:2010作者:Joel R Gever; Rothschild Soto; Robert A Henningsen; Renee S Martin; David H Hackos; Sandip Panicker; Werner Rubas; Ian B Oglesby; Michael P Dillon; Marcos E Milla; Geoffrey Burnstock; Anthony P D W Ford

药效评价Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.

期刊:Molecular pharmacology发表年份:2010作者:Colleen M Niswender; Kari A Johnson; Nicole R Miller; Jennifer E Ayala; Qingwei Luo; Richard Williams; Samir Saleh; Darren Orton; C David Weaver; P Jeffrey Conn

药效评价Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2010作者:M Shobo; Y Kondo; H Yamada; T Mihara; N Yamamoto; M Katsuoka; K Harada; K Ni; N Matsuoka

药效评价Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.

期刊:The international journal of neuropsychopharmacology发表年份:2010作者:Jason M Dwyer; Brian J Platt; Stacey J Sukoff Rizzo; Claudine M Pulicicchio; Caitlin Wantuch; Mei-Yi Zhang; Terri Cummons; Liza Leventhal; Corey N Bender; Jean Zhang; Dianne Kowal; Shendi Lu; S Johannes R Rajarao; Deborah L Smith; Adam D Shilling; Ji