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药效评价Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist.

期刊:British journal of pharmacology发表年份:2010作者:M G Cascio; L A Gauson; L A Stevenson; R A Ross; R G Pertwee

药效评价Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.

期刊:Journal of medicinal chemistry发表年份:2010作者:Paul A Glossop; Charlotte A L Lane; David A Price; Mark E Bunnage; Russell A Lewthwaite; Kim James; Alan D Brown; Michael Yeadon; Christelle Perros-Huguet; Michael A Trevethick; Nicholas P Clarke; Robert Webster; Rhys M Jones; Jane L Burrows; Neil Fe

药效评价A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

期刊:The Journal of neuroscience : the official journal of the Society for Neuroscience发表年份:2010作者:Thong C Ma; Aline Campana; Philipp S Lange; Hsin-Hwa Lee; Kasturi Banerjee; J Barney Bryson; Lata Mahishi; Shabnam Alam; Roman J Giger; Stephen Barnes; Sidney M Morris; Dianna E Willis; Jeffrey L Twiss; Marie T Filbin; Rajiv R Ratan

药效评价Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2010作者:Tadashi Ishibashi; Tomoko Horisawa; Kumiko Tokuda; Takeo Ishiyama; Masaaki Ogasa; Rie Tagashira; Kenji Matsumoto; Hiroyuki Nishikawa; Yoko Ueda; Satoko Toma; Hitomi Oki; Norihiko Tanno; Ikutaro Saji; Akira Ito; Yukihiro Ohno; Mitsutaka Nakamura