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心血管疾病Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism.

期刊:Biochemical pharmacology发表年份:2017作者:Jo-Anne Baltos; Elizabeth A Vecchio; Matthew A Harris; Cheng Xue Qin; Rebecca H Ritchie; Arthur Christopoulos; Paul J White; Lauren T May

心血管疾病A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2017作者:Alastair G Kerr; Lawrence C S Tam; Ashley B Hale; Milena Cioroch; Gillian Douglas; Sarina Agkatsev; Olivia Hibbitt; Joseph Mason; James Holt-Martyn; Carole J R Bataille; Graham M Wynne; Keith M Channon; Angela J Russell; Richard Wade-Martins

心血管疾病FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.

期刊:Nature communications发表年份:2017作者:Nicoletta C Surdo; Marco Berrera; Andreas Koschinski; Marcella Brescia; Matias R Machado; Carolyn Carr; Peter Wright; Julia Gorelik; Stefano Morotti; Eleonora Grandi; Donald M Bers; Sergio Pantano; Manuela Zaccolo

心血管疾病The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2.

期刊:The Journal of biological chemistry发表年份:2017作者:Shiro Fukuda; Shunbun Kita; Yoshinari Obata; Yuya Fujishima; Hirofumi Nagao; Shigeki Masuda; Yoshimitsu Tanaka; Hitoshi Nishizawa; Tohru Funahashi; Junichi Takagi; Norikazu Maeda; Iichiro Shimomura