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代谢疾病A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

期刊:Molecular pharmacology发表年份:2016作者:Denise Wootten; Christopher A Reynolds; Cassandra Koole; Kevin J Smith; Juan C Mobarec; John Simms; Tezz Quon; Thomas Coudrat; Sebastian G B Furness; Laurence J Miller; Arthur Christopoulos; Patrick M Sexton

代谢疾病Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1.

期刊:European journal of pharmacology发表年份:2016作者:Cecilia Nilsson; Thomas Kruse Hansen; Christian Rosenquist; Bolette Hartmann; János T Kodra; Jesper F Lau; Trine Ryberg Clausen; Kirsten Raun; Anette Sams

代谢疾病Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

期刊:Angewandte Chemie (International ed. in English)发表年份:2016作者:Johannes Broichhagen; Natalie R Johnston; Yorrick von Ohlen; Helena Meyer-Berg; Ben J Jones; Stephen R Bloom; Guy A Rutter; Dirk Trauner; David J Hodson

代谢疾病Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.

期刊:European journal of medicinal chemistry发表年份:2016作者:Peihong Liu; Yongli Du; Lianhua Song; Jingkang Shen; Qunyi Li