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代谢疾病Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.

期刊:Scientific reports发表年份:2016作者:Mohamed A Shehata; Anne C Nøhr; Delphine Lissa; Christoph Bisig; Vignir Isberg; Kirsten B Andersen; Kasper Harpsøe; Fredrik Björkling; Hans Bräuner-Osborne; David E Gloriam

代谢疾病AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor.

期刊:The Biochemical journal发表年份:2016作者:Linda Cederblad; Birgitta Rosengren; Erik Ryberg; Nils-Olov Hermansson

代谢疾病The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.

期刊:Amino acids发表年份:2016作者:Nitin A Patil; Ross A D Bathgate; Martina Kocan; Sheng Yu Ang; Julien Tailhades; Frances Separovic; Roger Summers; Johannes Grosse; Richard A Hughes; John D Wade; Mohammed Akhter Hossain

代谢疾病Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor.

期刊:Biochemical pharmacology发表年份:2016作者:Denise Wootten; Christopher A Reynolds; Kevin J Smith; Juan C Mobarec; Sebastian G B Furness; Laurence J Miller; Arthur Christopoulos; Patrick M Sexton