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药效评价A conservative, single-amino acid substitution in the second cytoplasmic domain of the human Serotonin2C receptor alters both ligand-dependent and -independent receptor signaling.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2008作者:Kelly A Berg; John Dunlop; Teresa Sanchez; Michelle Silva; William P Clarke

药效评价Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2008作者:N D Sonawane; Olga Zegarra-Moran; Wan Namkung; Luis J V Galietta; A S Verkman

药效评价Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.

期刊:Molecular genetics and metabolism发表年份:2008作者:Adriana M Montaño; Hirotaka Oikawa; Shunji Tomatsu; Tatsuo Nishioka; Carole Vogler; Monica A Gutierrez; Toshihiro Oguma; Yun Tan; Jeffrey H Grubb; Vu Chi Dung; Amiko Ohashi; Ken-ichi Miyamoto; Tadao Orii; Yukio Yoneda; William S Sly

药效评价Identification of non-lipid LPA3 antagonists by virtual screening.

期刊:Bioorganic & medicinal chemistry发表年份:2008作者:James I Fells; Ryoko Tsukahara; Yuko Fujiwara; Jianxiong Liu; Donna H Perygin; Daniel A Osborne; Gabor Tigyi; Abby L Parrill