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代谢疾病Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.

期刊:PloS one发表年份:2014作者:John A Corbin; Vinay Bhaskar; Ira D Goldfine; Daniel H Bedinger; Angela Lau; Kristen Michelson; Lisa M Gross; Betty A Maddux; Hua F Kuan; Catarina Tran; Llewelyn Lao; Masahisa Handa; Susan R Watson; Ajay J Narasimha; Shirley Zhu; Raphael Levy; Lynn W

代谢疾病A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.

期刊:BMC pharmacology & toxicology发表年份:2014作者:Tharappel M Anil; Anilkumar Dandu; KrishnaReddy Harsha; Jaideep Singh; Nitya Shree; Venkatesh Satish Kumar; Mudigere N Lakshmi; Venkategowda Sunil; Chandrashekaran Harish; Gundalmandikal V Balamurali; Baisani S Naveen Kumar; Aralakuppe S Gopala; Shiv

代谢疾病Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes.

期刊:Metabolism: clinical and experimental发表年份:2014作者:Hussein N Yassine; Alexandra Belopolskaya; Christina Schall; Craig S Stump; Serrine S Lau; Peter D Reaven

代谢疾病Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus.

期刊:PloS one发表年份:2014作者:Tadeusz Kolodka; Matthew L Charles; Arvind Raghavan; Ilian A Radichev; Christina Amatya; Jacob Ellefson; Alexei Y Savinov; Abhijeet Nag; Mark S Williams; Mark S Robbins