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药效评价Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

期刊:Journal of medicinal chemistry发表年份:2008作者:Les P Miranda; Katherine A Winters; Colin V Gegg; Ankita Patel; Jennifer Aral; Jason Long; Jingwen Zhang; Stephanie Diamond; Mark Guido; Shanaka Stanislaus; Mark Ma; Hongyan Li; Mark J Rose; Leszek Poppe; Murielle M Véniant

药效评价Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.

期刊:Molecular pharmacology发表年份:2008作者:Mieke Gouwy; Sofie Struyf; Samuel Noppen; Evemie Schutyser; Jean-Yves Springael; Marc Parmentier; Paul Proost; Jo Van Damme

药效评价An intracellular allosteric site for a specific class of antagonists of the CC chemokine G protein-coupled receptors CCR4 and CCR5.

期刊:Molecular pharmacology发表年份:2008作者:Glen Andrews; Carolyn Jones; Keith A Wreggett

药效评价Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.

期刊:The Biochemical journal发表年份:2008作者:Cédric Claperon; Raphael Rozenfeld; Xavier Iturrioz; Nicolas Inguimbert; Mayumi Okada; Bernard Roques; Bernard Maigret; Catherine Llorens-Cortes