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药效评价Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.

期刊:Journal of medicinal chemistry发表年份:2008作者:Michael E Kort; Irene Drizin; Robert J Gregg; Marc J C Scanio; Lei Shi; Michael F Gross; Robert N Atkinson; Matthew S Johnson; Gregory J Pacofsky; James B Thomas; William A Carroll; Michael J Krambis; Dong Liu; Char-Chang Shieh; Xufeng Zhang; Griceld

药效评价Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.

期刊:British journal of pharmacology发表年份:2008作者:A K Bassil; R A Borman; E M Jarvie; R J McArthur-Wilson; R Thangiah; E Z H Sung; K Lee; G J Sanger

药效评价In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.

期刊:Neurochemical research发表年份:2008作者:Jennifer L Mathews; Brian S Fulton; S Stevens Negus; John L Neumeyer; Jean M Bidlack

药效评价N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.

期刊:Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology发表年份:2008作者:Niels H Jensen; Ramona M Rodriguiz; Marc G Caron; William C Wetsel; Richard B Rothman; Bryan L Roth