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代谢疾病Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.

期刊:The Journal of biological chemistry发表年份:2013作者:Gwen Lomberk; Adrienne Grzenda; Angela Mathison; Carlos Escande; Jin-San Zhang; Ezequiel Calvo; Laurence J Miller; Juan Iovanna; Eduardo N Chini; Martin E Fernandez-Zapico; Raul Urrutia

代谢疾病Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.

期刊:Bioorganic & medicinal chemistry发表年份:2013作者:Matshawandile Tukulula; Mathew Njoroge; Grace C Mugumbate; Jiri Gut; Philip J Rosenthal; Samuel Barteau; Judith Streckfuss; Olivier Heudi; Jacques Kameni-Tcheudji; Kelly Chibale

代谢疾病Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion.

期刊:The Journal of pharmacology and experimental therapeutics发表年份:2013作者:Hirotsugu Tanaka; Shigeru Yoshida; Hiroyuki Oshima; Hideaki Minoura; Kenji Negoro; Takao Yamazaki; Shuichi Sakuda; Fumiyoshi Iwasaki; Tetsuo Matsui; Masayuki Shibasaki

代谢疾病A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice.

期刊:Diabetologia发表年份:2013作者:V K Bhat; B D Kerr; S Vasu; P R Flatt; V A Gault