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代谢疾病Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.

期刊:Journal of medicinal chemistry发表年份:2012作者:Nobuyuki Negoro; Shinobu Sasaki; Masahiro Ito; Shuji Kitamura; Yoshiyuki Tsujihata; Ryo Ito; Masami Suzuki; Koji Takeuchi; Nobuhiro Suzuki; Junichi Miyazaki; Takashi Santou; Tomoyuki Odani; Naoyuki Kanzaki; Miyuki Funami; Toshimasa Tanaka; Tsuneo Yas

代谢疾病Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator.

期刊:The Journal of biological chemistry发表年份:2012作者:John T Fisher; Xiaoming Liu; Ziying Yan; Meihui Luo; Yulong Zhang; Weihong Zhou; Ben J Lee; Yi Song; Chenhong Guo; Yujiong Wang; Gergely L Lukacs; John F Engelhardt

代谢疾病Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

期刊:Molecular pharmacology发表年份:2012作者:Francis S Willard; Denise Wootten; Aaron D Showalter; Emilia E Savage; James Ficorilli; Thomas B Farb; Krister Bokvist; Jorge Alsina-Fernandez; Sebastian G B Furness; Arthur Christopoulos; Patrick M Sexton; Kyle W Sloop

代谢疾病Amorfrutins are potent antidiabetic dietary natural products.

期刊:Proceedings of the National Academy of Sciences of the United States of America发表年份:2012作者:Christopher Weidner; Jens C de Groot; Aman Prasad; Anja Freiwald; Claudia Quedenau; Magdalena Kliem; Annabell Witzke; Vitam Kodelja; Chung-Ting Han; Sascha Giegold; Matthias Baumann; Bert Klebl; Karsten Siems; Lutz Müller-Kuhrt; Annette Schürmann; Ri