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心血管疾病Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

期刊:Journal of medicinal chemistry发表年份:2010作者:Luc Roumen; Joris W Peeters; Judith M A Emmen; Ilona P E Beugels; Erica M G Custers; Marcel de Gooyer; Ralf Plate; Koen Pieterse; Peter A J Hilbers; Jos F M Smits; Jef A J Vekemans; Dirk Leysen; Harry C J Ottenheijm; Henk M Janssen; J J Rob Hermans

心血管疾病Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin.

期刊:Biochemistry发表年份:2010作者:Matthew W Parker; Lance M Hellman; Ping Xu; Michael G Fried; Craig W Vander Kooi

心血管疾病By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.

期刊:The Journal of biological chemistry发表年份:2010作者:Xavier Iturrioz; Romain Gerbier; Vincent Leroux; Rodrigo Alvear-Perez; Bernard Maigret; Catherine Llorens-Cortes

心血管疾病A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate.

期刊:Biological & pharmaceutical bulletin发表年份:2010作者:Kiyoaki Yonesu; Tsuyoshi Nakamura; Yumiko Mizuno; Chie Suzuki; Takahiro Nagayama; Susumu Satoh; Futoshi Nara